Journal article
Cognitive network reorganization following surgical control of seizures in Lennox-Gastaut syndrome
AEL Warren, AS Harvey, DF Abbott, SJ Vogrin, C Bailey, A Davidson, GD Jackson, JS Archer
Epilepsia | WILEY | Published : 2017
DOI: 10.1111/epi.13720
Abstract
We previously observed that adults with Lennox-Gastaut syndrome (LGS) show abnormal functional connectivity among cognitive networks, suggesting that this may contribute to impaired cognition. Herein we report network reorganization following seizure remission in a child with LGS who underwent functional magnetic resonance imaging (fMRI) before and after resection of a cortical dysplasia. Concurrent electroencephalography (EEG) was acquired during presurgical fMRI. Presurgical and postsurgical functional connectivity were compared using (1) graph theoretical analyses of small-world network organization and node-wise strength; and (2) seed-based analyses of connectivity within and between fiv..
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Awarded by National Imaging Facility
Funding Acknowledgements
We thank the patients and their families for participating in this research. We also thank Michael Kean for coordinating MRI scanning. This study was supported by the National Health and Medical Research Council of Australia (NHMRC), project grant number 628725 (John S. Archer and David F. Abbott) and practitioner fellowship number 1060312 (Graeme D. Jackson). Aaron E.L. Warren is supported by an Australian Government Research Training Program Scholarship. David F. Abbott is supported by a National Imaging Facility Fellowship. We acknowledge the facilities and the scientific and technical assistance of the National Imaging Facility at the Florey node, and the support of the Victorian Government through the Operational Infrastructure Support Grant.